When you are in a hurry and need to generate data fast, DeltaPi-4 is your choice.īoth instruments measure surface tension with Kibron's thin wire probes (DyneProbes) from small subphase volumes. Further, the choice of materials eliminates unwanted non-specific surface effects.ĭeltaPi is a single-channel model, while DeltaPi-4 is equipped with four parallel microbalances, increasing significantly the throughput of experiments. One milligram of an antimicrobial peptide, for instance, is sufficient for a comprehensive characterization of its lipid-binding properties. The volume of the magnetically stirred subphase is minimally 150 microliters, which keeps your material consumption very low.
#Deltagraph 6 series
Along similar lines, recent findings have demonstrated the key role of lipid membranes in promoting the formation of toxic oligomers by Alzheimer Abeta peptide, prions, alpha-synuclein, and IAPP (amylin).ĭeltaPi series of Langmuir-tensiometers allow you to detect the penetration of drugs, peptides/proteins and nucleic acids into monolayers of specified lipid composition and at precisely controlled lateral packing density. phosphatidylinositols (PIPs) in controlling cytoskeleton-membrane interactions. Drug-lipid and protein-lipid interactions have emerged as a new, very exciting area in drug discovery, deciphering the roles of e.g. In these studies lipid monolayers have paved way to breakthroughs in the elucidation of the molecular mechanisms of action of lung surfactants, antimicrobial peptides, lipid signaling, blood coagulation, and cell adhesion, just to name a few examples. We innovate instruments for your innovative science.īiomembranes and lipids are entering the forefront of biosciences, biotechnology and drug discovery. Kibron DeltaPi and DeltaPi-4 are novel types of instruments: Langmuir-tensiometers, which allow you to measure the binding of drugs, peptides, and proteins to lipid membranes - easily and with unparalled sensitivity. Kibron's unique single and 4-channel Langmuir-tensiometers
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